The Clots in Legs Or sTockings after Stroke (CLOTS) 3 trial: a randomised controlled trial to determine whether or not intermittent pneumatic compression reduces the risk of post-stroke deep vein thrombosis and to estimate its cost-effectiveness.

Authors: Dennis M, Sandercock P, Graham C, Forbes J.

Source: Health Technol Assess. 2015 Sep;19(76):1-90. doi: 10.3310/hta19760.

Venous thromboembolism (VTE) is a common cause of death and morbidity in stroke patients. There are few data concerning the effectiveness of intermittent pneumatic compression (IPC) in treating patients with stroke. Clots in Legs Or sTockings after Stroke (CLOTS) 3 was a multicentre, parallel-group, randomised controlled trial which allocated patients via a central randomisation system to IPC or no IPC.

The authors concluded that IPC is an effective and inexpensive method of reducing the risk of DVT and improving survival in immobile stroke patients

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