Authors: Szkup M, Jurczak A, Brodowska A, Brodowska A, Noceń I, Chlubek D, Laszczyńska M, Karakiewicz B, Grochans E
Biol Trace Elem Res. 2017 Mar;176(1):56-63
Numerous observations suggest a possible connection between the levels of Mg, Zn, Fe, and Zn and the incidence of depressive symptoms. Depression is two to three times more common in women than in men. The menopausal period is extremely conducive to depressive disorders. The aim of this study was to assess the severity of depressive symptoms in postmenopausal women depending on the levels of Mg, Zn, Ca, Cu, and Fe. The study included 198 healthy postmenopausal women at the average age of 56.26Â Â±Â 5.55Â years. In the first part of the study, standardized research tools were used, namely the Primary Care Evaluation of Mental Disorders (PRIME-MD) and the Beck Depression Inventory (BDI). The second part involved biochemical analysis of Mg, Zn, Ca, Cu, and Fe levels in blood serum. The lowest Cu levels were observed in women without depressive symptoms (1.07Â Â±Â 0.22Â mg/l) and the highest in those with severe depressive symptoms (1.19Â Â±Â 0.17Â mg/l), (pÂ â¤Â 0.05). The lowest Mg levels were observed in women with depressive symptoms (14.28Â Â±Â 2.13Â mg/l), and the highest in women without depressive symptoms (16.30Â Â±Â 3.51Â mg/l), (pÂ â¤Â 0.05). The average serum Mg levels (15.75Â Â±Â 3.23Â mg/l) decreased compared to the reference values (18.77-24Â mg/l). What is striking is a potential relation between the levels of Mg and Cu and depressiveness. Our results indicate to a higher vulnerability to depression in a group of women with lower levels of Mg and higher levels of Cu.