Nephrotic syndrome in infants and children: pathophysiology and management

Authors: Downie, M.L., Gallibois, C., Parekh, R.S. & Noone, D.G.

Source: Paediatr Int Child Health. 2017 Sep 15:1-11. doi: 10.1080/20469047.2017.1374003. [Epub ahead of print]

Nephrotic syndrome is defined by nephrotic-range proteinuria (≥40 mg/m2/hour or urine protein/creatinine ratio ≥200 mg/mL or 3+ protein on urine dipstick), hypoalbuminaemia (<25 g/L) and oedema. This review focuses on the classification, epidemiology, pathophysiology, management strategies and prognosis of idiopathic nephrotic syndrome of childhood, and includes a brief overview of the congenital forms.

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